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This marked elevation in LVEDP suggests central congestion, irrespective of no change in afterload (systemic pressure), and is a hallmark of heart failure 20

Lu P, Graham L, Wang Y, Wu D, Tuszynski M

Sleep disruption changes the microbiome, as is shown in experiments where alterations in gut bacterial profiles were found in mice with circadian rhythm mutations or rats with chronic sleep deprivation ( Several probiotics and prebiotics have been shown to have positive effects on sleep, which could be interpreted to mean that sleep health can be managed by supporting the MGBA (Thompson et al., 2020)

Integrating exposomics and multi-omic data will also be essential for advancing personalized medicine