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Based on affinity chemical proteomics, the chloroacetamide part of the RSL3 structure is essential for its activity

Finally, bombesin antagonists have not been explored in asthma

However, robust quantitative translation between administered experimental doses and plausible human internal burdens remains highly uncertain due to variability in exposure assessment assumptions, limited size-resolved data on internal PET burdens in humans (particularly for the nanoscale fraction), and methodological constraints in detecting and characterising sub-micrometre particles in complex biological matrices