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Update on the evidence, with recommendations"

The tobacco plant is native to the Americas and is believed to have been first domesticated in the region that is now Mexico and Central America

However, the authors also emphasize that these studies only amount to a level of limited evidence, and that [w]hether or not the levels of exposure are high enough to contribute to human carcinogenesis remains to be determined. Additionally, [t]here is no available evidence whether or not e-cigarette use is associated with intermediate cancer endpoints in humans, the report says

This is why traditionally it is employed also as a preventative or maintenance mechanism to prevent future illness