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Kidney stones are frequently passed without complications, using only conservative treatment such as pain relief and hydration (Aliotta 2015

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These effects were associated with increased F-actin formation and activation of focal adhesion kinase (FAK) and paxillin phosphorylation, signaling events central to cell attachment and cytoskeletal remodeling during tissue repair processes [4]

USP8 inhibitor combined with ferroptosis inducer can significantly inhibit tumor growth and promote the infiltration of CD8+T cells in the tumor, and further improve the therapeutic effect of PD-1/PD-L1 blocking antibodies (155)