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Enzymes such as acyl-CoA synthetase long-chain family member 4 (ACSL4) play a vital role in synthesizing phosphatidylethanolamine-containing PUFAs (PE-PUFAs) and are thus key ferroptosis regulators

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The extrinsic pathway is initiated by the binding of proapoptotic ligands to death receptors on the cell surface, leading to the formation of the death-inducing signaling complex (DISC) and the activation of caspases (Qiao et al., 2024)

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