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The accumulation of mtDNA mutations with aging and disease jeopardizes respiratory capacity, leading to bioenergetic failure, oxidative stress, and neuronal vulnerability

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Interestingly, senescence-associated NAC genes (senNACs), key regulators of leaf senescence, were also found to be rapidly and strongly induced by H 2 O 2 treatment in both leaves and roots ( Distinct from the positive role of ROS in senescence, NO can both provoke and impede this process, dependent upon its concentration and subcellular location

Wang X, Lin H, Xu S, Jin Y, Zhang R