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However, the variation in the consumption of substances or frequency of behaviors within the surveyed literature may indicate that traditional approaches in psychiatric comorbidities [135] and problem behavior theory [13] may not be a viable approach when assessing disordered consumption of substances and resulting behaviors

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However, PAHs and their metabolites, which are relatively strong the aryl hydrocarbon receptor (AhR) ligands, exert both anti-estrogenic and estrogenic effects subsequently inhibiting or enhancing estrogenic signaling via crosstalk between AhR and estrogen receptors (ERs) or interfere with the AhR-controlled enzymes [41, 44]

In addition, the review was limited to the published academic literature and did not have the opportunity to review unpublished works