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Mechanistic insights: granulosa and cumulus cell impact Mechanistically, the follicular fluid (FF) in PCOS constitutes a unique inflammatoryoxidative niche in which neutrophil-derived products can exert direct cytotoxic effects on granulosa and cumulus cells

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Tang M, Abbas HA, Negrao MV, Ramineni M, Hu X, Hubert SM, Fujimoto J, Reuben A, Varghese S, Zhang J, Li J, Chow CW, Mao X, Song X, Lee WC, Wu J, Little L, Gumbs C, Behrens C, Moran C, Weissferdt A, Lee JJ, Sepesi B, Swisher S, Cheng C, Kurie J, Gibbons D, Heymach JV, Wistuba II, Futreal PA, Kalhor N, Zhang J

Each of these consequences independently worsens depressive symptoms