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In particular, nano-formulation strategiesincluding polymeric nanoparticles, lipid-based nanocarriers, nanoemulsions, and micellar systemshave shown promise in improving solubility, stability, and pharmacokinetic behavior

It is important to note that data provided in this excellent review include plasma, urine, and oral fluid but not solid tissues or cerebrospinal fluid (CSF)

An orange peel extract in which HD is the main compound can protect rat liver from CCl4-induced injury by lowering the levels of AST and ALT, and by increasing the content of glutathione, the activities of SOD and glutathione peroxidase ( 2.5.1.2 Effects of HD on hepatic lipid metabolism HD has been reported to have a therapeutic effect on lipid disorders in the liver

103 Pineda-MolinaE.KlattP.VazquezJ.MarinaA.Garcia De LacobaM.Perez-SalaD.et al (2001)