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Most rodent studies used: 10 micrograms/kg 100 micrograms/kg Administration routes varied by study: Intraperitoneal injection Subcutaneous injection Oral administration in drinking water Example reference: Sikiric et al., 2018 These dosages reflect controlled laboratory conditions and are not generalised outside experimental models

While acute pain and inflammation are natural responses to injuries or infections, chronic pain and inflammation cause pain signals to persist long after the initial trigger has resolved

Its plasma concentration declines with age (~200 ng/mL at 20 years, ~80 ng/mL at 60 years), an observation that has fed the hypothesis of involvement in tissue ageing

Anyone evaluating treatment should use a licensed clinician and FDA-approved or properly regulated prescription pathways, not research-use products