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In certain embodiments, the pharmacokinetics of the otic formulations or compositions described herein are determined by injecting the formulation on or near the round window membrane of a test animal (including by way of example, a guinea pig, a chinchilla, or a rat)

The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge

In barrier-disruption models, GHK-Cu has been reported to support recovery of stratum-corneum lipids, tight-junction proteins, and ceramide synthesis