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Lee S, Lee SM, Lee SH, Choi WK, Park SJ, Kim DY, et al

Clinical trials did not include pregnant or breastfeeding women, children, elderly individuals over 65, or those with active malignancy or severe organ dysfunction

November 21 Product: Jazz and Zymeworks Ziihera Indication: HER2-positive biliary tract cancer With the FDAs approval of Ziihera on Thursday, Jazz Pharmaceuticals and Zymeworks will go toe-to-toe with AstraZeneca and Daiichi Sankyo, whose antibody-drug conjugate Enhertu (fam-trastuzumab deruxtecan-nxki) was given a broad tumor-agnostic approval in April 2024

Unlike other toxicities, it lacks objective biomarkers and can be multifactorial in origin