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In essence, each component supports different steps of metabolic pathways, for example, energy generation from carbohydrates and fats requires B, B, B, and B in sequence

Stacking at moderate doses for each compound produces complementary effects that targeting one pathway alone cannot replicate, even at supra-therapeutic doses

Some individuals may struggle to absorb B12 through diet alone especially those with certain dietary restrictions or medical conditions

For the LEfSe analysis, an alpha of 0.05 was set for the KruskalWallis tests among classes, and per-sample normalization was performed to bring the sum of the values to 1 M