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These agents proved to be effective in PsA as well and, despite increasing evidence of the differences between PsA and RA, they have become an important part of the treatment algorithm for both diseases

Immunosenescence contributes to: Increased infection risk Slower recovery from illness Reduced vaccine responsiveness Chronic inflammation Greater susceptibility to age-related diseases At the same time , many older adults experience "inflammaging," a state of persistent low-grade inflammation that accelerates biological aging

What Has Been Studied

This selective mechanism is the foundation of FOXO4-DRIs research utility