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993 DFO reduces nigrostriatal iron in patients with PD, and 36 weeks of DFO treatment significantly reduces PD scores compared to placebo in early-stage patients with PD who have never been treated with levodopa (NCT02655315)

Histological studies have demonstrated disorganization of collagen fiber alignment, increased vascularity, mucoid degeneration, and loss of fibroblast density (Table 1) (Nyland et al., 2020)

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In addition, free radicals that could cause degenerative changes linked with aging, 11,105 DNA, or the buildup of physiological and structural damage are the primary cause of aging