glutathione and lungs The Treatment of Pulmonary Diseases Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Role of glutathione in immunity

Polevoi D

Mol Aspects Med 30 , 1-12 (2009)

Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants

PMCID: PMC4757669