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40 , 42 Cagrilintide also exhibited a rapid dissociation with a residence time of 36 min 28 that is comparable for all AMYRs whereas sCT showed slow rates of dissociation from all receptors (4560 min) confirming previous studies performed in vivo and in vitro .51, 52, 53 This effect was associated with a longer duration of action of the peptide in cAMP production with a sustained response for sCT while cagrilintide cAMP activation returned to baseline within a few hours

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Semaglutide works by mimicking the GLP-1 hormone, targeting receptors in the brain involved in appetite regulation