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Outcomes included THI and VAS scores, as well as serum 5-hydroxytryptamine (5-HT) and -aminobutyric acid (GABA) levels before and after treatment

343 According to a 2020 systematic review and meta-analysis that included 60 randomized controlled trials with a total of 4,129 patients, omega-3 fatty acid supplementation appeared to decrease the incidence of cardiovascular death by 55% in CKD patients on hemodialysis, though it did not appear to reduce mortality overall

even if the rats were orally administered to their maximum dose (1,600 mg/kg/d), and no adverse reactions occurred (Schauss et al., 2011