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The idea behind pairing the two is that they work on different problems

Brzoska T, Luger TA, Maaser C, Abels C, Bhm M

In the liver model, proliferating HepaRG cells were used as an adequate alternative to human primary hepatocytes, the "gold standard" for in vitro drug testing, due to their availability, comparable CYP enzyme expression and presence of relevant efflux and uptake transporters 65,66,67