Conceptualization: AD, EG Methodology: AD, EG, AG, HS, JC, MLV, PLC, CC, TG, OF, AMK, CL, BJ Investigation: AD, EG, AG, MLV, HS, TG, OF, DK Visualization: AD, EG, AG, HS Funding acquisition: AD, RB, GWM Project administration: AD, RB, GWM Supervision: AD Writing original draft: AD, EG Writing review & editing: AD, EG, AG, HS, JC, MLV, PLC, CC, TG, OF, AMK, CL, DK, RB, GWM Competing interests Authors declare that they have no competing interests
When Residual Schizophrenia was included in the model, the R 2 of the model increased to 0.12, a medium effect size, f 2 = 0.14
But the nervous system is plastic, meaning it can change and adapt
Uricosuric agents like dotinurad enhance UA excretion by targeting specific enzymes involved in purine metabolism