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chondroitin sulphate and hyaluronic acid protect the urinary tract lining, inhibit bacterial adhesion, and modulate the immune response while NAC exhibits antimicrobial effects, modulates the immune response, reduces oxidative stress, and may have a role in recurrent UTI prevention [28,37,60,85]

Pathogenesis of Inflammation Since the brain does not mount classical allergic reactions and IgE cannot cross the blood-brain barrier (BBB), it is therefore unsurprising that mast cells, although distributed systemically, normally lack surface expression of the high-affinity IgE receptor (FcRI)