HDACi have been classified into four major classes, based on the chemical nature of the inhibitor ( Figure 5 )
This result also confirms that selenium can inhibit the tumorigenesis caused by chemical carcinogens mainly in the initiation and promotion stages of chemical carcinogenesis, and its related mechanism may be related to the fact that selenium reduces the activity of hydroxylase that can activate carcinogens such as aromatic amine hydroxylase in the early stage of carcinogenesis, and increases the activity of glucuronosyltransferase that can release the toxicity of carcinogens, thus blocking the activation of the metabolism of carcinogens in the organism
c ch s hnh thnh v pht trin ca hc t melamin, kch thch ti to t bo mi ti sng hn
J Biol Chem 276:29596602 Fratelli M, Demol H, Puype M, Casagrande S, Eberini I, Salmona M, Bonetto V, Mengozzi M, Duffieux F, Miclet E, Bachi A, Vanekerckhove J, Gianazza E, Ghezzi P (2002) Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
