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Our results show that glutathione efflux from hepatocytes results in high local concentrations of both glutathione and cysteine in liver sinusoids, which transforms the nanoparticle surface chemistry, reduces its affinity to serum protein and significantly alters its blood retention, targeting and clearance

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In contrast, the VPA-exposed group showed substantial pathological alterations, including mitochondrial pathologies featuring cristae disorganization and membrane rupture with alternating swelling and shrinkage (Fig