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Its efficacy is demonstrated through the reduction of liver fat, improvement of liver function markers, and regulation of specific genes such as Atf3 and Acox2, supporting its development as a targeted therapy (82)

Moreover, therapeutic strategies targeting the gut-brain axis, including interventions aimed at restoring gut microbial composition, metabolite balance, and reducing inflammation, could be beneficial in mitigating CKD progression associated with chronic stress and mental health issues

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Finally, the full realization of SFNs potential will require the continued convergence of cutting-edge technologies from diverse fields