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Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions

While malfunctions of NO-system significance are generally implicated in various disturbances, the presented findings (i.e., schizophrenia) claim both decreased and increased NO-system function in etiopathology and, thereby, controversy in therapy, either L-NAME or L-arginine [59,70,124]

Rather than interacting with receptors on the plasma membrane of their target cells, the gasotransmitters (soluble gases such as nitric oxide and carbon monoxide, as unconventional neurotransmitters) can cross the cell membrane and act directly on molecules inside the cell [36]