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YW: Conceptualization, Supervision, Writing review and editing

However, this is not certain and has not been consistently seen in humans

Authors contributions YO managed most part of the study, proposed the hypothesis, proposed the study design, performed experiment, performed statistical analysis and wrote the manuscript

5.3 Advantages of intranasal delivery Intranasal (IN) delivery offers several advantages over other common routes, such as oral administration, particularly in enhancing therapeutic efficacy and patient compliance