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Fluctuating serotonin levels have recently been implicated in the after-effects of STN DBS due to data reporting that (1) cognitive and depressive symptoms develop after stimulation and (2) anti-Parkinsonian drugs reduce serotonin in the prefrontal cortex and hippocampus, and (3) selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine enhance responsiveness to neurostimulation [371,373,373]

Joint pain is not listed among the most common adverse reactions in current prescribing information

[65] GABA directly injected to the brain has been reported to have both stimulatory and inhibitory effects on the production of growth hormone, depending on the physiology of the individual