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This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

Potential risks include hormone imbalances, effects on blood sugar levels, and increased IGF-1 (insulin-like growth factor) levels, which may lead to other risks over time

The resulting elevated TSH promotes thyroid gland enlargement, or goiter, with metabolic slowing in affected animals

Reduced cellular wear with age Research with SS-31 looks at how cells maintain integrity over longer timeframes