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In untreated animals, these symptoms progressed significantly, while Gepon administration provided notable protection

Refrigeration dampens molecular motion, essentially putting degradation reactions into slow motion rather than stopping them completely

The success rate decreases remarkably if patients have symptoms refractory to PPI therapy, patients have atypical symptoms other than heartburn or acid regurgitation, there is poor documentation of objective evidence of reflux disease, or the procedure is performed by less experienced surgeons