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Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77

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Changes in actin polymerization status can affect focal adhesion signaling complexes, integrin-mediated signaling, and transcriptional responses that govern cellular movement and structural adaptation