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[15] Around 1592, the Spanish galleon San Clemente brought 50 kilograms (110 lb) of tobacco seed to the Philippines over the Acapulco-Manila trade route

While the decline in combustible tobacco product use is good news, the rate of decline was much less among those aged 35 years, where cigarette use remained high and only slowly declined between 2015 and 2023

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And so the boundary issue is largely determined by, its a scientific classification, but there are many public health models for how that can be managed in reliable, defensible, valid ways to work for policy