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In the sections that follow, we build on this conceptual framework to examine how major proteostasis machineries contribute to cellular and organ-level resilience and how their failure drives pathology across cardiovascular, cancer, metabolic, neurodegenerative and autoimmune disorders and highlight therapeutic strategies aimed at reinforcing proteostasis resilience

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In reality, aberrant T cells are equally if not more important key initiators of the observed systemic inflammation, as they stimulate proliferation, maturation, and differentiation of B cells, thereby enhancing autoantibody production and class-switching in SLE

J Hepatol 2017;66:78797 [DOI] [PMC free article] [PubMed] [Google Scholar] 118.Choi DY, Ban JO, Kim SC, Hong JT.CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver