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Western blot analysis Western blot analyses were performed according to a standard protocol using primary antibodies, including anti-p-Akt, anti-Akt, anti-p-ERK1/2, anti-ERK1/2, anti-p-p38, anti-p38 antibodies (Cell Signaling Technology, Danvers, MA, USA), anti-OTUD3 (Sigma-Aldrich, MABS1819M), anti-ZFP36 (Merck Millipore, ABE285), and anti-FBXW7 (Abcam, ab109617)

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