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Physical recovery from exercise or injury: Exercise is great, but it traumatizes muscle cells

Controls received vehicle only, BSO-only group received 125 mg/kg twice daily on days 1, 2 and 3 via intraperitoneal injection, L-PAM-only group received 10 mg/kg dose on days 2 and 3 given intravenously into the lateral tail vein, and the L-PAM+BSO group received both drugs as per above

Our results indicate that IRE1-regulated ferroptosis sensitivity is independent of XBP1 activation, as forced expression of activated XBP1 in IRE1-null cells failed to restore sensitization to ferroptosis (Fig