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Therefore, CB-839 has been tested in many clinical trials, including colorectal cancer (NCT02861300), triple-negative breast cancer (NCT02071862), renal cell carcinoma (NCT03163667), melanoma (NCT02771626), and others (Table 2)

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Lontoft nevertheless pointed to the need for a diverse range of treatments to address both obesity and associated health risks, such as cardiovascular disease, sleep apnea and liver disease areas in which the drugs have already been shown to be making headway

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