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This shift is crucial because microglia play dual roles while chronic M1 activation promotes damage through cytokine release and oxidative stress, M2 activation supports tissue repair and resolution of inflammation (Tang and Le, 2016)

I., Mir, M

We will use the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) [18] checklist since this tool combines the reporting of several measures to reduce bias with indicators of external validity