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In 1998, Andrew Fire and Craig Mello reported that double-stranded RNA (dsRNA) had potent gene silencing effects in Caenorhabditis elegans , 38 a discovery they termed RNA interference (RNAi)

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Interestingly, the levels of these polyamines are significantly reduced in fibrotic lungs, and their supplementation has been shown to alleviate oxidative stress and attenuate fibrosis [16, 77,78,79]