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The implications of tobacco smoking on acute postoperative pain: a prospective observational study

The close link between smoking and the development of cardiovascular disease is particularly well-established, with several studies showing that the risk of myocardial infarction is overall 2-3 times higher in smokers than in non-smokers, and even much higher in heavy smokers (one pack or more per day) (Figure 2)

Combination treatments show 25-35% success rates, with many individuals requiring multiple quit attempts before achieving long-term cessation