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In turn, this reduces their membrane permeability, necessitating carrier-mediated transport for biliary and renal excretion

This review interprets HTY-related mechanisms through direct chemical actions such as radical scavenging and metal chelation, indirect cellular associations indicated by alterations in downstream markers (e.g., Nrf2, NF-B, AMPK-related changes), and translational relevance, evidenced when effects become evident at physiologically attainable exposures and/or in human studies

Ibuprofen potentiates the in vivo antifungal activity of fluconazole against Candida albicans murine infection