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[6] A comprehensive review by Mayer in 2014 suggests an LD50 of 6.5-13mg/kg (500-1000mg for adults), which is more consistent with actual fatalities and dog studies

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This addiction primarily stems from the presence of nicotine, a potent psychoactive substance found in tobacco, according to an article by the Center of Addiction and Mental Health titled Nicotine Dependence. The addictive nature of tobacco leads individuals to develop a tolerance, necessitating higher amounts to achieve the same effects, ultimately reinforcing the cycle of dependence