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This treatment alleviates the symptoms and improves the associated biochemical abnormalities, and in some studies has been shown to increase plasma T 3 and T 4 levels by suppression of the autoimmune process(106)

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

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Therefore, GSH itself may not be effective at direct reduction of reactive oxygen species under physiological conditions