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TKIs interfere with cellular signaling pathways, which may contribute to inner ear toxicity (Rizk et al

It is involved in the regulation of growth hormones and promotes cell differentiation and regulation

Because the follow-up time was fairly short, these results may have been caused by reverse causality, where a developing, undiagnosed condition was influencing IGF-1 levels at the time when the samples were taken

Children presenting neurological signs or symptoms, those unable to take oral medication, individuals with known malabsorption syndromes, infants under 6 months old, and patients using medications that may interfere with vitamin B12 absorption are typically treated with a parenteral protocol (1)