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It has been reported that Akkermansia muciniphila , a novel probiotic, increases the abundance of Firmicutes , reduces intestinal inflammation, and promotes the restoration of gut microbiota structure in DSS-induced colitic mice [159]

Activation of oncogenes and loss of tumor suppressors lead to the increased production of superoxide via mitochondria and NADPH oxidase (NOX) pathways ( 2 O 2 ), a more stable and stronger oxidizing molecule, through the action of superoxide dismutase enzymes (SOD)

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