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In the letter the ACLU sent to the FDA opposing a menthol ban, they concluded, In the end, tobacco policy will no longer be the responsibility of regulators regulating, but of police policing

Over time, repeated exposure to cigarette smoke causes an accumulation of these mutations

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With too little seratonin in the gaps between nerve cells, the target receptors on the receiving nerve cells dont fire enough to keep the mood-elevating pathway active, and depression results