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Our previous transcriptomic profiling further linked shunt responsiveness to gene programs involved in mitochondrial function and proteostasis 40

REIMAGINE 2, reported in February 2026, showed superior HbA1c reductions of up to 1.91 percentage points from a baseline of 8.2 per cent, beating both individual components on glucose control and weight

Sewastjanow-Silva, M, Xiao, L, Nogueras Gonzalez, G, Wang, X, Hofstetter, WL , Swisher, SG, Mehran, RJ, Sepesi, B, Bhutani, M, Weston, B, Coronel, E, Waters, R, Rogers, JE, Smith, J, Lyons, L, Reilly, N, Yao, JC, Ajani, JA, Blum Murphy, M

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