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(1997) Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study

Fatigue is also a symptom of high blood sugar, as people taking the type 2 diabetes drug may experience, the Mayo Clinic says

Common side effects Injection-site reactions: mild redness, tenderness, swelling, occasional bruising - usually resolve within hours Skin flushing / warmth - brief, related to vasodilation Transient fatigue in the first 12 weeks of intensive protocols Mild headache - usually dose-related Higher-dose theoretical concerns Copper accumulation - each 2 mg injection adds roughly 0.03 mg of elemental copper, trivial next to the 0.92.2 mg from a normal diet

Concentration = 5,000 mcg / 2 ml = 2,500 mcg per ml