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The activation of ASK1, induced by H 2 O 2 or hypoxia/reoxygenation, leads to elevated levels of soluble receptor for VEGF (sFlt-1) [203], which has anti-angiogenic properties [150, 204]

revealed that inhibiting the 15LOX-2/PEBP1 complex, even without directly targeting 15-LOX, can reduce the production of 15-hydroperoxy-eicosatetraenoyl phosphatidylethanolamine (15-HpETE-PE), thereby effectively suppressing lipid peroxidation and ferroptosis ( in vitro and in vivo by specifically targeting the 15LOX-2/PEBP1 complex, which has become a critical target in ferroptosis research (Dar et al., 2023)

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PMID: 33500247 Autophagy Porcine reproductive and respiratory syndrome virus hijacks the non-canonical enzymatic function of PHGDH to arrest autophagic flux for viral replication