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The challenge involves reduced appetite making it harder to consume enough of any food

For people with type 2 diabetes, the SURPASS trial series demonstrated exceptional glycemic control alongside weight loss, which is why the compound received its first approval for diabetes before the obesity indication followed

Current evidence Although B12 supplements are commonly taken to boost energy levels, there is currently no evidence that higher B12 levels increase energy in people with adequate B12 levels

Known and theoretical safety concerns include: Retatrutide (and the GLP-1 receptor agonist class): Nausea, vomiting, diarrhoea, and reduced appetite are the most commonly reported side effects