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A deficiency in vitamin B12 levels can cause various dermatologic symptoms, including nail discolouration, hyper-pigmentation, hair changes, vitiligo, and angular stomatitis (inflamed and cracked mouth corners)

Nanoparticles comprise at least one hydrophobic, water-insoluble and water-indispersible polymer or copolymer emulsified in a solution or aqueous dispersion of surfactants, phospholipids or fatty acids