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Loss of appetite suppression

Novo Nordisk is seeking a next-generation obesity treatment after the runaway success of its Ozempic diabetes and Wegovy obesity treatments have lately come under pressure from supply constraints and increased competition from copycat compounded drug makers

Across models spanning tendons, ligaments, muscle, bone and the GI (gastrointestinal) tract, the same core mechanisms appear repeatedly, which is either a sign of genuine pleiotropic biology or publication bias

It may downregulate ACTH release and affect cortisol dynamics, contributing to studies on neuroendocrine recovery and homeostasis under chronic or acute stress